Multiple Cytokines-Producing Pleomorphic Carcinoma of Lung with Metastasis to the Small Intestine

Satoshi Hara; Keita Hosoi; Yasuhiko Suga; Tetsuo Takata; Hiroyuki Degami; Yoshinori Kinoshita; Kyongyob Min

doi:10.5761/atcs.cr.13-00202

Case Reports

Multiple Cytokines-Producing Pleomorphic Carcinoma of Lung with Metastasis to the Small Intestine

Satoshi Hara, Keita Hosoi, Yasuhiko Suga, Tetsuo Takata, Hiroyuki Degami, Yoshinori Kinoshita, Kyongyob Min

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Keywords: cytokine, pleomorphic carcinoma, lung, G-CSF, TNF-α

JOURNAL FREE ACCESS

2014 Volume 20 Issue Supplement Pages 666-668

DOI https://doi.org/10.5761/atcs.cr.13-00202

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Abstract

A 58-year-old man underwent upper lobectomy for primary pleomorphic carcinoma of the lung. Nine months later, the pleomorphic carcinoma was recurred with marked peripheral leukocytosis and an elevated C-reactive protein. Chest and abdominal computed tomography (CT) revealed enlarged mediastinal lymph nodes and a bulky tumor in the small intestine. An enterectomy was performed and the intestinal tumor was removed. Immunostaining revealed tumor cells positive for G-CSF and TNF-α as well as an increased level of serum G-CSF and TNF-α. We describe a rare case of G-CSF and TNF-α producing pleomorphic carcinoma of the lung with metastasis to the small intestine.

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