Bioscience, Biotechnology, and Biochemistry
Online ISSN : 1347-6947
Print ISSN : 0916-8451
Food & Nutrition Science Notes
Comparative Activities of the S-Enantiomer and Racemic Forms of Equol on Bone Fragility in Ovariectomized Mice
Yoshifumi KIMIRAShin-ichi KATSUMATAKazuharu SUZUKIYoshiko ISHIMITomomi UENOShigeto UCHIYAMAHerman ADLERCREUTZMariko UEHARA
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2012 Volume 76 Issue 5 Pages 1018-1021

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Abstract

We compared the effects of the S-enantiomer and racemic forms of equol on bone using ovariectomized (OVX) mice. Femoral bone mineral density and bone strength decreased in the OVX mice, but not in OVX mice administered 0.5 mg/d S-equol. This, however, did not hold for racemic equol. Serum and urine S-equol concentrations were higher in the mice administered S-equol than in those administered racemic equol. These results suggest that the inhibitory effects of S-equol on bone fragility in OVX mice are greater than those of racemic equol.

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© 2012 by Japan Society for Bioscience, Biotechnology, and Agrochemistry
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