ε-Viniferin Is More Effective Than Its Monomer Resveratrol in Improving the Functions of Vascular Endothelial Cells and the Heart

Nahla ZGHONDA; Shigeki YOSHIDA; Shoji EZAKI; Yoshie OTAKE; Chie MURAKAMI; Ahmed MLIKI; Abdelwahed GHORBEL; Hitoshi MIYAZAKI

doi:10.1271/bbb.110975

Food & Nutrition Science Regular Papers

ε-Viniferin Is More Effective Than Its Monomer Resveratrol in Improving the Functions of Vascular Endothelial Cells and the Heart

Nahla ZGHONDA, Shigeki YOSHIDA, Shoji EZAKI, Yoshie OTAKE, Chie MURAKAMI, Ahmed MLIKI, Abdelwahed GHORBEL, Hitoshi MIYAZAKI

Author information

Keywords: angiotensin-converting enzyme, ε-viniferin, resveratrol, spontaneously hypertensive rat, vascular endothelial cell

JOURNAL FREE ACCESS

2012 Volume 76 Issue 5 Pages 954-960

DOI https://doi.org/10.1271/bbb.110975

View "Advance Publication" version (May 7, 2012).

Details

Abstract

The present study compared the effects of resveratrol and its dimer ε-viniferin on vascular endothelial cells (VECs) functions, and on the blood pressure and cardiac mass of spontaneously hypertensive rats (SHRs). Treatment of VECs with these compounds enhanced cell proliferation via nitric oxide generation and protected the cells from oxidative stress by suppressing increases in intracellular oxygen species. ε-Viniferin was more potent than resveratrol in most of these effects. ε-Viniferin, but not resveratrol inhibited angiotensin-converting enzyme activity in vitro. Three weeks of ε-viniferin treatment (5 mg/kg) reduced the systolic blood pressure and improved the whole cardiac mass and left ventricle mass indexes in SHRs. In contrast, resveratrol administration (2.5 mg/kg) failed to lower the blood pressure and significantly improve these mass indexes. These data suggest that ε-viniferin as well as resveratrol may be involved in protecting the functions of VECs and the heart.

Corresponding author

Register with J-STAGE for free!