The Role of Acetylation in the Subcellular Localization of an Oncogenic Isoform of Translation Factor eIF5A

Muhammad ISHFAQ; Kazuhiro MAETA; Satoko MAEDA; Toru NATSUME; Akihiro ITO; Minoru YOSHIDA

doi:10.1271/bbb.120620

Biochemistry & Molecular Biology Notes

The Role of Acetylation in the Subcellular Localization of an Oncogenic Isoform of Translation Factor eIF5A

Muhammad ISHFAQ, Kazuhiro MAETA, Satoko MAEDA, Toru NATSUME, Akihiro ITO, Minoru YOSHIDA

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Keywords: eIF5A2, acetylation, hypusination, subcellular localization, HDAC

JOURNAL FREE ACCESS

2012 Volume 76 Issue 11 Pages 2165-2167

DOI https://doi.org/10.1271/bbb.120620

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Abstract

Mammalian cells express two isoforms of eIF5A, eIF5A1 and eIF5A2, but little is known about the function of eIF5A2. Here we report that eIF5A2 is reversibly acetylated at lysine-47. HDAC6 and SIRT2 were identified as the enzymes responsible for deacetylating eIF5A2. Analysis using acetylation-deficient mutants indicated that acetylation regulates the subcellular localization of eIF5A2.

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