Improved High-Fat Diet-Induced Glucose Intolerance by an Oral Administration of Phytosphingosine

Itsuo MURAKAMI; Susumu MITSUTAKE; Naoyuki KOBAYASHI; Junko MATSUDA; Akemi SUZUKI; Tatsuro SHIGYO; Yasuyuki IGARASHI

doi:10.1271/bbb.120644

Food & Nutrition Science Notes

Improved High-Fat Diet-Induced Glucose Intolerance by an Oral Administration of Phytosphingosine

Itsuo MURAKAMI, Susumu MITSUTAKE, Naoyuki KOBAYASHI, Junko MATSUDA, Akemi SUZUKI, Tatsuro SHIGYO, Yasuyuki IGARASHI

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Keywords: phytoceramide, phytosphingosine, sphingolipid δ(4)-desaturase/C4-hydroxylase isoform 2 (DES2), sphingolipid, PPAR

JOURNAL FREE ACCESS

2013 Volume 77 Issue 1 Pages 194-197

DOI https://doi.org/10.1271/bbb.120644

View "Advance Publication" version (January 7, 2013).

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Abstract

We have previously reported that phytoceramide and phytosphingosine (PHS) stimulated the transcriptional activity of peroxisome proliferator-activated receptor γ (PPARγ) in cells. PPARγ is a therapeutic target for type 2 diabetes. We found in this study that an oral administration of PHS improved diet-induced glucose intolerance in mice. Since PHS is highly expressed in yeast, PHS in fermented foods may improve diabetes.

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