Identification of a Nitric Oxide Generation-Stimulative Principle in Scutellariae radix

Ziyang CHEN; Kenichi NIHEI; Hideyuki TANAKA; Yasushi UDA; Yukihito KABUYAMA

doi:10.1271/bbb.120800

Analytical Chemistry Note

Identification of a Nitric Oxide Generation-Stimulative Principle in Scutellariae radix

Ziyang CHEN, Kenichi NIHEI, Hideyuki TANAKA, Yasushi UDA, Yukihito KABUYAMA

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Keywords: Scutellariae radix, baicalin, endothelial nitric oxide, human umbilical vein endothelial cells

JOURNAL FREE ACCESS

2013 Volume 77 Issue 3 Pages 657-659

DOI https://doi.org/10.1271/bbb.120800

View "Advance Publication" version (March 7, 2013).

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Abstract

Scutellariae radix (SR, from the roots of Scutellaria baicalensis Georgi) is thought to regulate blood pressure. In this study, HPLC-based purification coupled with MS, NMR analysis revealed that baicalin, a major flavone in SR, stimulates endothelial NO generation, suggesting its potential as an ingredient in medicinal food and beverage to treat hypertension.

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