Inhibited Apoptosis of C2C12 Myoblasts by a Eupatorium chinense var. simplicifolium Root Extract

Jin-Ho LEE; Min-Ho JUNG; Yong-Hyeon LEE; Yusu SHIN; Han-Sung KIM; Jürgen SCHREIBER; Tack-Joong KIM

doi:10.1271/bbb.130333

Food & Nutrition Science Notes

Inhibited Apoptosis of C₂C₁₂ Myoblasts by a Eupatorium chinense var. simplicifolium Root Extract

Jin-Ho LEE, Min-Ho JUNG, Yong-Hyeon LEE, Yusu SHIN, Han-Sung KIM, Jürgen SCHREIBER, Tack-Joong KIM

Author information

Jin-Ho LEE
Division of Biological Science and Technology, Yonsei-Fraunhofer Medical Device Lab, College of Science and Technology, Yonsei University
Min-Ho JUNG
Division of Biological Science and Technology, Yonsei-Fraunhofer Medical Device Lab, College of Science and Technology, Yonsei University
Yong-Hyeon LEE
Division of Biological Science and Technology, Yonsei-Fraunhofer Medical Device Lab, College of Science and Technology, Yonsei University
Yusu SHIN
Department of Herbal Crop Research, National Institute of Horticultural and Herbal Science
Han-Sung KIM
Department of Biomedical Engineering, Yonsei-Fraunhofer Medical Device Lab, College of Health Science, Yonsei University
Jürgen SCHREIBER
NUGA Lab GmbH, Fraunhofer Institut für Zerstörungsfreie Prüfverfahren Institutsteil Dresden
Tack-Joong KIM
Division of Biological Science and Technology, Yonsei-Fraunhofer Medical Device Lab, College of Science and Technology, Yonsei University

Keywords: Eupatorium chinense var. simplicifolium, muscle atrophy, HSP70

JOURNAL FREE ACCESS

2013 Volume 77 Issue 10 Pages 2134-2136

DOI https://doi.org/10.1271/bbb.130333

View "Advance Publication" version (October 7, 2013).

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Abstract

We investigated the effects of a Eupatorium chinense var. simplicifolium (EUC) root extract on muscle disorders and explored the underlying mechanism for oxidative stress-induced C₂C₁₂ myoblast damage. An EUC pre-treatment reduced the decreased cell viability after an H₂O₂ treatment. The heat shock protein (HSP) 70 level increased, and the phosphorylation of Jun amino-terminal kinases (JNKs) decreased in the EUC-pre-treated C₂C₁₂ myoblasts. The results of the present study demonstrate the potential benefit of a herbal medicine in treating oxidative stress-related muscle disorders.

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