Circulation Journal
Online ISSN : 1347-4820
Print ISSN : 1346-9843
ISSN-L : 1346-9843
Cardiovascular Intervention
Prevalence of Inherited Thrombophilia in Patients With Documented Stent Thrombosis
Dennis ZavalloniPatrizia PresbiteroCorrado LodigianiRuggiero MangoTommaso CogliatiIlaria QuagliaElena CorradaGrazia-Loredana MendolicchioGabriele-Luigi GaspariniMarco-Luciano RossiPaola FerrazziGuido BelliPaolo PagnottaLidia-Luciana Rota
Author information
JOURNAL FREE ACCESS

2012 Volume 76 Issue 8 Pages 1874-1879

Details
Abstract

Background: Stent thrombosis (ST) is a multi-factorial process involving different mechanisms. The impact of inherited coagulation disorders in the genesis of ST has never been assessed. The aim of the present study was to evaluate the prevalence of G1691A Factor V Leiden mutation, G20210A Factor II (prothrombin) mutation and C677T homozygous methylenetetrahydrofolate reductase (MTHFR) polymorphism in patients with ST. Methods and Results: The prevalence of the aforementioned gene variations was assessed in 127 patients: 50 admitted for ST and 77 previously treated with percutaneous coronary intervention not developing ST. A control cohort of 529 healthy volunteers was sampled from the same geographical area. Patients with ST were carriers of at least 1 gene variation in 28% of cases. The prevalence of G1691A Factor V Leiden mutation (odds ratio [OR]=0.64; 95% confidence interval [CI]: 0.04-10.5), G20210A Factor II mutation (OR=0.63; 95% CI: 0.12-3.28) and C677T MTHFR homozygous polymorphism (OR=1.13; 95% CI: 0.47-2.72) did not differ significantly among patients with or without ST. The logistic regression model did not show a significant association between gene variations and ST (OR=0.61; 95% CI: 0.24-1.60; P=0.32). Conclusions: A specific association between studied gene variations and ST has not been detected. The relatively high prevalence of at least 1 gene anomaly in such a rare subset of patients, and its consequences in term of secondary prevention therapy, suggests that screening for thrombophilia might be justifiable in cases of ST.  (Circ J 2012; 76: 1874–1879)

Content from these authors
© 2012 THE JAPANESE CIRCULATION SOCIETY
Previous article Next article
feedback
Top