Radiofrequency Catheter Ablation of Persistent Atrial Fibrillation Decreases a Sleep-Disordered Breathing Parameter During a Short Follow-up Period

Yoshihisa Naruse; Hiroshi Tada; Makoto Satoh; Mariko Yanagihara; Hidekazu Tsuneoka; Yumi Hirata; Takeshi Machino; Hiro Yamasaki; Miyako Igarashi; Kenji Kuroki; Yoko Ito; Yukio Sekiguchi; Kazutaka Aonuma

doi:10.1253/circj.CJ-12-0014

Arrhythmia/Electrophysiology

Radiofrequency Catheter Ablation of Persistent Atrial Fibrillation Decreases a Sleep-Disordered Breathing Parameter During a Short Follow-up Period

Yoshihisa Naruse, Hiroshi Tada, Makoto Satoh, Mariko Yanagihara, Hidekazu Tsuneoka, Yumi Hirata, Takeshi Machino, Hiro Yamasaki, Miyako Igarashi, Kenji Kuroki, Yoko Ito, Yukio Sekiguchi, Kazutaka Aonuma

Author information

Yoshihisa Naruse
Cardiovascular Division, Institute of Clinical Medicine, Graduate School of Comprehensive Human Sciences, University of Tsukuba
Hiroshi Tada
Cardiovascular Division, Institute of Clinical Medicine, Graduate School of Comprehensive Human Sciences, University of Tsukuba
Makoto Satoh
Sleep Medicine Division, Institute of Clinical Medicine, Graduate School of Comprehensive Human Sciences, University of Tsukuba
Mariko Yanagihara
Sleep Medicine Division, Institute of Clinical Medicine, Graduate School of Comprehensive Human Sciences, University of Tsukuba
Hidekazu Tsuneoka
Cardiovascular Division, Institute of Clinical Medicine, Graduate School of Comprehensive Human Sciences, University of Tsukuba
Yumi Hirata
Sleep Medicine Division, Institute of Clinical Medicine, Graduate School of Comprehensive Human Sciences, University of Tsukuba
Takeshi Machino
Cardiovascular Division, Institute of Clinical Medicine, Graduate School of Comprehensive Human Sciences, University of Tsukuba
Hiro Yamasaki
Cardiovascular Division, Institute of Clinical Medicine, Graduate School of Comprehensive Human Sciences, University of Tsukuba
Miyako Igarashi
Cardiovascular Division, Institute of Clinical Medicine, Graduate School of Comprehensive Human Sciences, University of Tsukuba
Kenji Kuroki
Cardiovascular Division, Institute of Clinical Medicine, Graduate School of Comprehensive Human Sciences, University of Tsukuba
Yoko Ito
Cardiovascular Division, Institute of Clinical Medicine, Graduate School of Comprehensive Human Sciences, University of Tsukuba
Yukio Sekiguchi
Cardiovascular Division, Institute of Clinical Medicine, Graduate School of Comprehensive Human Sciences, University of Tsukuba
Kazutaka Aonuma
Cardiovascular Division, Institute of Clinical Medicine, Graduate School of Comprehensive Human Sciences, University of Tsukuba

Keywords: Atrial fibrillation, Catheter ablation, Sleep apnea syndrome

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2012 Volume 76 Issue 9 Pages 2096-2103

DOI https://doi.org/10.1253/circj.CJ-12-0014

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Abstract

Background: Obstructive sleep apnea (OSA) is often associated with atrial fibrillation (AF), but the impact of radiofrequency catheter ablation (RFCA) for AF on sleep apnea syndrome is unknown. Methods and Results: A total of 25 patients (3 women; 61±6 years) with sleep apnea syndrome who underwent RFCA for drug-refractory, persistent AF were studied. Polysomnography was also performed 1 day before and 1 week after RFCA in all patients. The total number of central or OSA or hypopnea events was analyzed and compared. Among the 25 patients who all predominantly had obstructive apnea, the apnea-hypopnea index (AHI; median, 21, interquartile range [IQR]: 11–38 to median 15, IQR: 7–23; P=0.002) and obstructive type of apnea (median 10, IQR: 6–19 to median 7, IQR: 2–14; P=0.003) decreased after RFCA. In patients in whom sinus rhythm was restored and maintained after RFCA, the AHI decreased after RFCA (median 22, IQR: 15–38 to median 15, IQR: 7–23; P<0.01), but it did not in those who had AF recurrence (median 10, IQR: 9–11 to median 11, IQR: 10–16; P<0.05). There was a significant correlation between the outcome of RFCA and % change in the AHI (rs=0.569, P=0.003). Conclusions: In patients with sleep apnea syndrome and AF, restoring sinus rhythm by RFCA was significantly associated with a decrease in AHI (Clinical Trial Registration: Trial number, UMIN000005538). (Circ J 2012; 76: 2096–2103)

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