Background: This study compared older men and women with cardiovascular (CV) risk factors in terms of the effects of a 6-month exercise intervention on high-sensitivity C-reactive protein (hsCRP) levels, blood pressure (BP) and other risk factors. Methods and Results: Sixty older (age 61–79) overweight men and 71 such women with 2 or more risk factors (ie, systolic BP 130–179mmHg, non-fasting blood glucose 110–139mg/dl, and low-density lipoprotein cholesterol 120–219mg/dl) participated in a 6-month exercise intervention. The exercise program consisted of moderate-intensity bicycle exercise for ∼40min, performed on average 2.5 times per week. Systolic and diastolic BP reductions were found to be greater in women than in men (SBP, −10.6 vs. −5.5mmHg; DBP, −6.2 vs. −3.3mmHg; both P<0.05). Decreases in body mass index were larger in women than in men (P<0.05). There was no significant gender difference in the changes in blood glucose and lipid profiles and hsCRP levels. After adjustment for confounders (exercise frequency, weight loss, age, and baseline values), there were still significant gender differences in the SBP and DBP reductions. hsCRP reduction were similar in both genders even after adjusting for weight loss. Conclusions: There could be gender differences in the beneficial effects of exercise training on the potent CV risk factors of BP and body weight, but not on hsCRP.  (Circ J 2013; 77: 646–651)