Triterpene Saponins from Clethra barbinervis and Their Hyaluronidase Inhibitory Activities

Toshihiro Murata; Atsushi Suzuki; Nagisa Mafune; Eriko Sato; Toshio Miyase; Fumihiko Yoshizaki

doi:10.1248/cpb.c12-00566

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Triterpene Saponins from Clethra barbinervis and Their Hyaluronidase Inhibitory Activities

Toshihiro Murata, Atsushi Suzuki, Nagisa Mafune, Eriko Sato, Toshio Miyase, Fumihiko Yoshizaki

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Keywords: Clethra barbinervis, hyaluronidase inhibitor, triterpene saponin

JOURNAL FREE ACCESS

2013 Volume 61 Issue 2 Pages 134-143

DOI https://doi.org/10.1248/cpb.c12-00566

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Abstract

An extract of Clethra barbinervis with an inhibitory effect on hyaluronidase activity was fractionated guided by the results of an assay. From the active fractions, seven new triterpene saponins (1–4, 6–8) and a new lignan glycoside (14) were isolated together with 14 known compounds (5, 9–13, 15–22). Some of the saponins (2, 3, 9) were revealed as hyaluronidase inhibitors similar to epicatechin (17).

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