New ent-Abietane and ent-Kaurane Diterpenoids from Isodon rubescens

Xu Liu; Rui Zhan; Wei-Guang Wang; Xue Du; Xiao-Nian Li; Jian-Hong Yang; Peng Zhang; Yan Li; Jian-Xin Pu; Ji-Zhou Wu; Han-Dong Sun

doi:10.1248/cpb.c12-00697

Notes

New ent-Abietane and ent-Kaurane Diterpenoids from Isodon rubescens

Xu Liu, Rui Zhan, Wei-Guang Wang, Xue Du, Xiao-Nian Li, Jian-Hong Yang, Peng Zhang, Yan Li, Jian-Xin Pu, Ji-Zhou Wu, Han-Dong Sun

Author information

Xu Liu
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences
Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, Tongji School of Pharmacy, Huazhong University of Science and Technology
Rui Zhan
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences
Wei-Guang Wang
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences
Xue Du
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences
Xiao-Nian Li
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences
Jian-Hong Yang
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences
Peng Zhang
Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, Tongji School of Pharmacy, Huazhong University of Science and Technology
Yan Li
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences
Jian-Xin Pu
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences
Ji-Zhou Wu
Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, Tongji School of Pharmacy, Huazhong University of Science and Technology
Han-Dong Sun
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences

Keywords: Isodon rubescens, ent-abietane, ent-abierubesin, ent-kaurane, hubeirubesin

JOURNAL FREE ACCESS

2013 Volume 61 Issue 1 Pages 90-95

DOI https://doi.org/10.1248/cpb.c12-00697

Details

Abstract

Five new ent-abietane diterpenoids, ent-abierubesins A–E (1–5), and two new ent-kauranoids, hubeirubesins A and B (6, 7), together with three known diterpenoids (8–10), were isolated from the aerial parts of Isodon rubescens. Their structures were identified by means of extensive spectroscopic analysis, and the absolute stereochemistry of 1 was determined by single-crystal X-ray diffraction experiment.

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