Syntheses of 2-Deoxy-2,3-didehydro-N-acetylneuraminic Acid Analogues Modified by α-Acylaminoamido Groups at the C-4 Position Using Isocyanide-Based Four-Component Coupling and Biological Evaluation as Inhibitors of Human Parainfluenza Virus Type 1

Reiko Nishino; Takuya Hayakawa; Tadanobu Takahashi; Takashi Suzuki; Masayuki Sato; Kiyoshi Ikeda

doi:10.1248/cpb.c12-00834

Regular Articles

Syntheses of 2-Deoxy-2,3-didehydro-N-acetylneuraminic Acid Analogues Modified by α-Acylaminoamido Groups at the C-4 Position Using Isocyanide-Based Four-Component Coupling and Biological Evaluation as Inhibitors of Human Parainfluenza Virus Type 1

Reiko Nishino, Takuya Hayakawa, Tadanobu Takahashi, Takashi Suzuki, Masayuki Sato, Kiyoshi Ikeda

Author information

Keywords: human parainfluenza virus type 1, sialidase inhibitor, sialic acid, 4-isocyano Neu5Ac2en derivative, isocyanide-based four-component coupling

JOURNAL FREE ACCESS

2013 Volume 61 Issue 1 Pages 69-74

DOI https://doi.org/10.1248/cpb.c12-00834

Details

Abstract

Novel sialidase inhibitors 11 having an α-acylaminoamido group at the C-4 position of Neu5Ac2en 1 against human parainfluenza virus type 1 (hPIV-1) were synthesized using one-pot isocyanide-based four-component condensation, and their inhibitory activities against hPIV-1 sialidase were studied. Compound 11b showed inhibitory activity (IC₅₀=5.1 mM) against hPIV-1 sialidase. The degree of inhibition of 11b was much weaker than that of 1 (IC₅₀=0.3 mM).

Corresponding author

Register with J-STAGE for free!