Medicinal Flowers. XXXVIII. Structures of Acylated Sucroses and Inhibitory Effects of Constituents on Aldose Reducatase from the Flower Buds of Prunus mume

Katsuyoshi Fujimoto; Seikou Nakamura; Takahiro Matsumoto; Tomoe Ohta; Keiko Ogawa; Haruka Tamura; Hisashi Matsuda; Masayuki Yoshikawa

doi:10.1248/cpb.c12-01068

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Medicinal Flowers. XXXVIII. Structures of Acylated Sucroses and Inhibitory Effects of Constituents on Aldose Reducatase from the Flower Buds of Prunus mume

Katsuyoshi Fujimoto, Seikou Nakamura, Takahiro Matsumoto, Tomoe Ohta, Keiko Ogawa, Haruka Tamura, Hisashi Matsuda, Masayuki Yoshikawa

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Keywords: Prunus mume, mumeose, acylated sucrose, medicinal flower, aldose reductase, acylated quinic acid analog

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2013 Volume 61 Issue 4 Pages 445-451

DOI https://doi.org/10.1248/cpb.c12-01068

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Abstract

The methanolic extract from the flower buds of Prunus mume, cultivated in Zhejiang province, China, showed an inhibitory effect on aldose reductase. From the methanolic extract, five new acylated sucroses, mumeoses F–J, were isolated together with 29 known compounds. The chemical structures of the new compounds were elucidated on the basis of chemical and physicochemical evidence. The inhibitory effects of the isolated compounds on aldose reductase were also investigated. Acylated quinic acid analogs, which are one of the major compounds of the flower buds of P. mume, were shown to substantially inhibit aldose reductase. In particular, mumeic acid-A was found to exhibit a potent inhibitory effect [IC₅₀=0.4 µm].

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