Chemical and Pharmaceutical Bulletin
Online ISSN : 1347-5223
Print ISSN : 0009-2363
ISSN-L : 0009-2363
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Triterpenes with Cytotoxicity from the Leaves of Vernicia fordii
Yi-Hua Pei, Ok-Kyoung Kwon, Ji-Seon Lee, Hyuk-Jin Cha, Kyung-Seop Ahn, Sei-Ryang Oh, Hyeong-Kyu Lee , Young-Won Chin
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Keywords: Vernicia fordii, triterpene, cytotoxicity
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2013 Volume 61 Issue 6 Pages 674-677

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Abstract

Two new triterpenes, (1α,3β,8α,9β,10α,13α,14β)-9,10-dimethyl-25,26-dinorolean-5-en-1,3-diol (1) and (1α,3β,6β)-olean-12-en-1,3,6-triol (2) were isolated from the leaves of Aleurites fordii, together with five known triterpenes. The structures of isolates were established by one dimensional (1D)- and 2D-NMR spectroscopic data along with MS analysis. Of the isolated compounds, 1, 2 and 4 (daturadiol) displayed moderate cytotoxicities against two or more human cancer cell lines in HepG2 (hepatocellular carcinoma), SK-OV-3 (ovarian carcinoma), A-549 (lung carcinoma) and SNU-1 (gastric carcinoma).

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© 2013 The Pharmaceutical Society of Japan
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