Nagelamide I and 2,2′-Didebromonagelamide B, New Dimeric Bromopyrrole–Imidazole Alkaloids from a Marine Sponge Agelas sp.

Takahiro Iwai; Takaaki Kubota; Jane Fromont; Jun’ichi Kobayashi

doi:10.1248/cpb.c13-00821

Notes

Nagelamide I and 2,2′-Didebromonagelamide B, New Dimeric Bromopyrrole–Imidazole Alkaloids from a Marine Sponge Agelas sp.

Takahiro Iwai, Takaaki Kubota, Jane Fromont, Jun’ichi Kobayashi

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Keywords: marine sponge, Agelas sp., dimeric bromopyrrole–imidazole alkaloid, nagelamide I, 2,2′-didebromonagelamide B

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2014 Volume 62 Issue 2 Pages 213-216

DOI https://doi.org/10.1248/cpb.c13-00821

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Abstract

New dimeric bromopyrrole–imidazole alkaloids, nagelamide I (1) and 2,2′-didebromonagelamide B (2), have been isolated from an Okinawan marine sponge Agelas species. The structures of 1 and 2 were elucidated based on analyses of the spectral data. Nagelamide I (1) was the first symmetric dimeric bromopyrrole–imidazole alkaloid consisting of two subunits connected with a single bond.

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