Synthesis of Benzofuro[6,7-d]thiazoles, Benzofuro[7,6-d]thiazoles and 6-Arylaminobenzo[d]thiazole-4,7-diones as Antifungal Agent

Chung-Kyu Ryu; Ji-Hee Nho; Guohua Jin; Sun Young Oh; Soo Jung Choi

doi:10.1248/cpb.c14-00146

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Synthesis of Benzofuro[6,7-d]thiazoles, Benzofuro[7,6-d]thiazoles and 6-Arylaminobenzo[d]thiazole-4,7-diones as Antifungal Agent

Chung-Kyu Ryu , Ji-Hee Nho, Guohua Jin, Sun Young Oh, Soo Jung Choi

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Keywords: benzofuro[6,7-d]thiazole, benzofuro[7,6-d]thiazole, benzo[d]thiazole-4,7-dione, antifungal, antimicrobial, fungi

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2014 Volume 62 Issue 7 Pages 668-674

DOI https://doi.org/10.1248/cpb.c14-00146

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Abstract

Benzofuro[6,7-d]thiazoles, benzofuro[7,6-d]thiazoles and 6-arylaminobenzo[d]thiazole-4,7-diones were synthesized and tested for in vitro antifungal activity against Candida, Aspergillus species and Cryptococcus neoformans. Among them tested, many of synthesized compounds showed potent antifungal activity. The compounds 4d, 6e and 6h completely inhibited the growth of all Candida and Aspergillus species tested at the MIC level of 6.3 µg/mL. The results suggest that benzofuro[6,7-d]thiazoles and 6-arylaminobenzo[d]thiazole-4,7-diones would be promising antifungal agents.

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