Internal Medicine
Online ISSN : 1349-7235
Print ISSN : 0918-2918
ISSN-L : 0918-2918
CASE REPORTS
Rapidly Progressive Glomerulonephritis Associated with PR3-ANCA Positive Subacute Bacterial Endocarditis
Hirotaka FukasawaMaho HayashiNaoko KinoshitaSayaka IshigakiShinsuke IsobeYukitoshi SakaoAkihiko KatoYoshihide FujigakiRyuichi Furuya
Author information
JOURNAL OPEN ACCESS

2012 Volume 51 Issue 18 Pages 2587-2590

Details
Abstract

Patients with bacterial endocarditis often have renal complications. This report presents the case of an elderly man with rapidly progressive glomerulonephritis (RPGN) associated with subacute bacterial endocarditis (SBE) due to Enterococcus faecalis infection. The patient was positive for anti-proteinase 3-antineutrophil cytoplasmic antibody (PR3-ANCA) and rheumatoid factor (RF) with hypocomplementemia. Treatment for SBE with antibiotics and the surgical replacement of the affected valves resulted in an improvement of RPGN, the disappearance of PR3-ANCA and RF, and the normalization of hypocomplementemia. This rare case suggests the importance of recognizing the cause of positive PR3-ANCA, because SBE could be an occult cause of RPGN mimicking ANCA-associated vasculitis.

Content from these authors
© 2012 by The Japanese Society of Internal Medicine
Previous article Next article
feedback
Top