Multiple Gastric G1 Neuroendocrine Tumors with Venous and Lymphatic Invasion

Tetsuya Tatsuta; Tetsuro Yoshimura; Keisuke Hasui; Kaori Takasugi; Manabu Sawaya; Norihiro Hanabata; Tadashi Shimoyama; Hiroshi Kijima; Shinsaku Fukuda

doi:10.2169/internalmedicine.52.0083

CASE REPORTS

Multiple Gastric G1 Neuroendocrine Tumors with Venous and Lymphatic Invasion

Tetsuya Tatsuta, Tetsuro Yoshimura, Keisuke Hasui, Kaori Takasugi, Manabu Sawaya, Norihiro Hanabata, Tadashi Shimoyama, Hiroshi Kijima, Shinsaku Fukuda

Author information

Tetsuya Tatsuta
Department of Gastroenterology, Hirosaki University Graduate School of Medicine, Japan
Tetsuro Yoshimura
Department of Gastroenterology, Hirosaki University Graduate School of Medicine, Japan
Keisuke Hasui
Department of Gastroenterology, Hirosaki University Graduate School of Medicine, Japan
Kaori Takasugi
Department of Gastroenterology, Hirosaki University Graduate School of Medicine, Japan
Manabu Sawaya
Department of Gastroenterology, Hirosaki University Graduate School of Medicine, Japan
Norihiro Hanabata
Department of Gastroenterology, Hirosaki University Graduate School of Medicine, Japan
Tadashi Shimoyama
Department of Gastroenterology, Hirosaki University Graduate School of Medicine, Japan
Hiroshi Kijima
Department of Pathology and Bioscience, Hirosaki University Graduate School of Medicine, Japan
Shinsaku Fukuda
Department of Gastroenterology, Hirosaki University Graduate School of Medicine, Japan

Keywords: neuroendocrine tumor (NET), endocrine cell micronest (ECM), endoscopic submucosal dissection (ESD)

JOURNAL OPEN ACCESS

2013 Volume 52 Issue 15 Pages 1697-1701

DOI https://doi.org/10.2169/internalmedicine.52.0083

Details

Abstract

A 60-year-old woman was admitted for the treatment of a gastric neuroendocrine tumor (NET) associated with type A chronic atrophic gastritis. The lesion measured 10 mm in diameter, and a computed tomography scan did not reveal any metastatic lesions. Endoscopic submucosal dissection (ESD) was subsequently performed. A histological examination revealed three gastric NETs, two of which exhibited vessel invasion. Endocrine cell micronests associated with a high risk of recurrence were also observed. Therefore, the patient underwent total gastrectomy with lymph node dissection. Because vessel invasion can occur in patients with small gastric NET G1, the use of ESD should be considered to carefully estimate the presence of invasion.

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