Long-term Remission Achieved via Combined Chemotherapy and Radiotherapy in a Non-resectable Granulocyte Colony-stimulating Factor Producing Pleomorphic Carcinoma of the Lung

Masaki Yamamoto; Saki Manabe; Yusuke Moriyama; Hiroshi Ishii; Shintetsu Tanaka; Ryohei Takahashi; Koji Tomaru; Nobuaki Kobayashi; Makoto Kudo; Masahiro Sasaki; Yoshiaki Inayama; Takeshi Kaneko; Yoshiaki Ishigatsubo

doi:10.2169/internalmedicine.52.0701

CASE REPORTS

Long-term Remission Achieved via Combined Chemotherapy and Radiotherapy in a Non-resectable Granulocyte Colony-stimulating Factor Producing Pleomorphic Carcinoma of the Lung

Masaki Yamamoto, Saki Manabe, Yusuke Moriyama, Hiroshi Ishii, Shintetsu Tanaka, Ryohei Takahashi, Koji Tomaru, Nobuaki Kobayashi, Makoto Kudo, Masahiro Sasaki, Yoshiaki Inayama, Takeshi Kaneko, Yoshiaki Ishigatsubo

Author information

Masaki Yamamoto
Respiratory Medicine, Yokohama City University Hospital, Japan
Saki Manabe
Respiratory Medicine, Yokohama City University Hospital, Japan
Yusuke Moriyama
Respiratory Medicine, Yokohama City University Hospital, Japan
Hiroshi Ishii
Respiratory Medicine, Yokohama City University Hospital, Japan
Shintetsu Tanaka
Respiratory Medicine, Yokohama City University Hospital, Japan
Ryohei Takahashi
Respiratory Medicine, Yokohama City University Hospital, Japan
Koji Tomaru
Respiratory Medicine, Yokohama City University Hospital, Japan
Nobuaki Kobayashi
Respiratory Medicine, Yokohama City University Hospital, Japan
Makoto Kudo
Respiratory Medicine, Yokohama City University Hospital, Japan
Masahiro Sasaki
Respiratory Medicine, Yokohama City University Hospital, Japan
Yoshiaki Inayama
Department of Pathology, Yokohama City University Graduate School of Medicine, Japan
Takeshi Kaneko
Respiratory Disease Center, Yokohama City University Medical Center, Japan
Yoshiaki Ishigatsubo
Department of Internal Medicine and Clinical Immunology, Graduate School of Medicine & Faculty of Medicine, Yokohama City University, Japan

Keywords: lung cancer, pleomorphic carcinoma, granulocyte colony stimulating factor (G-CSF), chemotherapy, radiotherapy

JOURNAL OPEN ACCESS

2013 Volume 52 Issue 19 Pages 2259-2263

DOI https://doi.org/10.2169/internalmedicine.52.0701

Details

Abstract

The prognosis is poor for patients with advanced pleomorphic carcinoma of the lung due to the generally limited response to chemotherapy and/or radiotherapy. It has been suggested the production of granulocyte colony-stimulating factor (G-CSF) by cancer cells may aggravate the disease progression. We herein report a case of a 73-year-old Japanese man with advanced G-CSF-producing pleomorphic carcinoma of the lung. First-line chemotherapy with carboplatin and paclitaxel had been suspended. Subsequent radiotherapy achieved a moderate volume reduction and an amelioration of the excessive G-CSF-related complications. Six cycles of second-line chemotherapy with docetaxel administered with good results. These combined treatments resulted in long term survival without progression of the disease.

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