Papillary Squamous Cell Carcinoma of the Trachea Associated with Human Papillomavirus-18 Infection

Hisao Imai; Toshiaki Takahashi; Tetsuhiko Taira; Madoka Kimura; Yukiko Nakamura; Hirotsugu Kenmotsu; Tateaki Naito; Reiko Watanabe; Haruyasu Murakami; Yasuhisa Ohde; Masahiro Endo; Takashi Nakajima; Nobuyuki Yamamoto

doi:10.2169/internalmedicine.52.0736

CASE REPORTS

Papillary Squamous Cell Carcinoma of the Trachea Associated with Human Papillomavirus-18 Infection

Hisao Imai, Toshiaki Takahashi, Tetsuhiko Taira, Madoka Kimura, Yukiko Nakamura, Hirotsugu Kenmotsu, Tateaki Naito, Reiko Watanabe, Haruyasu Murakami, Yasuhisa Ohde, Masahiro Endo, Takashi Nakajima, Nobuyuki Yamamoto

Author information

Hisao Imai
Division of Thoracic Oncology, Shizuoka Cancer Center, Japan
Toshiaki Takahashi
Division of Thoracic Oncology, Shizuoka Cancer Center, Japan
Tetsuhiko Taira
Division of Thoracic Oncology, Shizuoka Cancer Center, Japan
Madoka Kimura
Division of Thoracic Oncology, Shizuoka Cancer Center, Japan
Yukiko Nakamura
Division of Thoracic Oncology, Shizuoka Cancer Center, Japan
Hirotsugu Kenmotsu
Division of Thoracic Oncology, Shizuoka Cancer Center, Japan
Tateaki Naito
Division of Thoracic Oncology, Shizuoka Cancer Center, Japan
Reiko Watanabe
Division of Diagnostic Pathology, Shizuoka Cancer Center, Japan
Haruyasu Murakami
Division of Thoracic Oncology, Shizuoka Cancer Center, Japan
Yasuhisa Ohde
Division of Thoracic Surgery, Shizuoka Cancer Center, Japan
Masahiro Endo
Division of Diagnostic Radiology, Shizuoka Cancer Center, Japan
Takashi Nakajima
Division of Diagnostic Pathology, Shizuoka Cancer Center, Japan
Nobuyuki Yamamoto
Division of Thoracic Oncology, Shizuoka Cancer Center, Japan

Keywords: tracheal cancer, squamous cell carcinoma, human papillomavirus type 18, p16

JOURNAL OPEN ACCESS

2013 Volume 52 Issue 24 Pages 2785-2788

DOI https://doi.org/10.2169/internalmedicine.52.0736

Details

Abstract

A 75-year-old man presented with the chief complaints of coughing and dyspnea. Chest computed tomography revealed narrowing of the trachea. A tumor measuring 40×33×15 mm in size that caused -90% reduction in the cross-sectional area of the trachea 4 cm above the carina was cauterized with high-frequency electrocautery via a rigid bronchoscope. A pathological examination revealed papillary squamous cell carcinoma with immunohistochemical p16 overexpression. Multiplex polymerase chain reaction confirmed human papillomavirus type 18 DNA in the tumor. At the 12-month follow-up visit following the administration of radiotherapy, the patient exhibited no local recurrence or distant metastasis.

Corresponding author

Register with J-STAGE for free!