Rapid Progression of Neuromuscular Disorder Related Cardiomyopathy in a Young Patient

Mayuko Hayashi; Hidekazu Tanaka; Tetsushi Yamamoto; Tomoko Lee; Hiroyuki Awano; Mariko Yagi; Takamitsu Imanishi; Nobuhide Hayashi; Yasuhiro Takeshima; Hiroya Kawai; Ken-ichi Hirata; Seiji Kawano

doi:10.2169/internalmedicine.52.1000

CASE REPORTS

Rapid Progression of Neuromuscular Disorder Related Cardiomyopathy in a Young Patient

Mayuko Hayashi, Hidekazu Tanaka, Tetsushi Yamamoto, Tomoko Lee, Hiroyuki Awano, Mariko Yagi, Takamitsu Imanishi, Nobuhide Hayashi, Yasuhiro Takeshima, Hiroya Kawai, Ken-ichi Hirata, Seiji Kawano

Author information

Mayuko Hayashi
Department of Clinical Laboratory, Kobe University Hospital, Japan
Hidekazu Tanaka
Division of Cardiovascular Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine, Japan
Tetsushi Yamamoto
Department of Clinical Laboratory, Kobe University Hospital, Japan
Tomoko Lee
Department of Pediatrics, Kobe University Graduate School of Medicine, Japan
Hiroyuki Awano
Department of Pediatrics, Kobe University Graduate School of Medicine, Japan
Mariko Yagi
Department of Pediatrics, Kobe University Graduate School of Medicine, Japan
Takamitsu Imanishi
Department of Clinical Laboratory, Kobe University Hospital, Japan
Nobuhide Hayashi
Department of Clinical Laboratory, Kobe University Hospital, Japan
Yasuhiro Takeshima
Department of Pediatrics, Kobe University Graduate School of Medicine, Japan
Hiroya Kawai
Division of Cardiovascular Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine, Japan
Ken-ichi Hirata
Division of Cardiovascular Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine, Japan
Seiji Kawano
Department of Clinical Laboratory, Kobe University Hospital, Japan
Department of Clinical Pathology and Immunology, Kobe University Graduate School of Medicine, Japan

Keywords: cardiomyopathy, echocardiography, heart failure, speckle-tracking, neuromuscular disorder

JOURNAL OPEN ACCESS
Supplementary material

2013 Volume 52 Issue 24 Pages 2771-2775

DOI https://doi.org/10.2169/internalmedicine.52.1000

Details

Abstract

An 11-year and 3-month-old boy with a neuromuscular disorder was admitted for dyspnea. Echocardiography revealed severe left ventricular dysfunction with an ejection fraction (EF) of 17%. However, the EF had been 57% when the patient was 10 years and 9 months old. The patient's clinical condition became refractory, and he died on the 155th day of hospitalization. Speckle-tracking analysis was retrospectively performed, which demonstrated that the global radial strain was within the normal range; however, the global longitudinal and circumferential strains were lower -than -normal 10 years and 9 months of age. Adult neuromuscular disorder-related secondary cardiomyopathy generally progresses slowly, although progression depends on the age of onset of cardiomyopathy.

Corresponding author

Register with J-STAGE for free!