Thyrotoxic Periodic Paralysis with Graves' Disease Leading to the Discovery of a Hidden Nonclassic 11β Hydroxylase Deficiency

Jin Hwa Kim; Geon Park; Sang Yong Kim; Hak Yeon Bae

doi:10.2169/internalmedicine.52.8032

CASE REPORTS

Thyrotoxic Periodic Paralysis with Graves' Disease Leading to the Discovery of a Hidden Nonclassic 11β Hydroxylase Deficiency

Jin Hwa Kim, Geon Park, Sang Yong Kim, Hak Yeon Bae

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Keywords: nonclassic 11β hydroxylase deficiency, congenital adrenal hyperplasia, thyrotoxic periodic paralysis

JOURNAL OPEN ACCESS

2013 Volume 52 Issue 1 Pages 85-88

DOI https://doi.org/10.2169/internalmedicine.52.8032

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Abstract

11β hydroxylase deficiency (OHD) is one of the main causes of congenital adrenal hyperplasia. There have been only a few reported cases of nonclassic 11β OHD, a milder form of the disease. It is difficult to detect occult nonclassic 11β OHD because patients present with no or mild symptoms. We herein present a case of thyrotoxic periodic paralysis (TPP) with Graves' disease leading to the discovery of a hidden nonclassic 11β OHD. In this case, increased levels of thyroid hormone seem to have induced symptoms of occult nonclassic 11β OHD and aggravated TPP.

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