Basal Insulin Requirements after Progesterone Treatment in a Type 1 Diabetic Pregnant Woman

Shugo Sasaki; Tetsuyuki Yasuda; Hideaki Kaneto; Akio Kuroda; Yukari Fujita; Keiko Fujisawa; Yukiko Tabuchi; Ryuichi Kasami; Taka-aki Matsuoka; Munehide Matsuhisa; Iichiro Shimomura

doi:10.2169/internalmedicine.52.8675

CASE REPORTS

Basal Insulin Requirements after Progesterone Treatment in a Type 1 Diabetic Pregnant Woman

Shugo Sasaki, Tetsuyuki Yasuda, Hideaki Kaneto, Akio Kuroda, Yukari Fujita, Keiko Fujisawa, Yukiko Tabuchi, Ryuichi Kasami, Taka-aki Matsuoka, Munehide Matsuhisa, Iichiro Shimomura

Author information

Shugo Sasaki
Department of Metabolic Medicine, Osaka University Graduate School of Medicine, Japan
Tetsuyuki Yasuda
Department of Metabolic Medicine, Osaka University Graduate School of Medicine, Japan
Hideaki Kaneto
Department of Metabolic Medicine, Osaka University Graduate School of Medicine, Japan
Akio Kuroda
Diabetes Therapeutics and Research Center, The University of Tokushima, Japan
Yukari Fujita
Department of Metabolic Medicine, Osaka University Graduate School of Medicine, Japan
Keiko Fujisawa
Department of Metabolic Medicine, Osaka University Graduate School of Medicine, Japan
Yukiko Tabuchi
Department of Metabolic Medicine, Osaka University Graduate School of Medicine, Japan
Ryuichi Kasami
Department of Metabolic Medicine, Osaka University Graduate School of Medicine, Japan
Taka-aki Matsuoka
Department of Metabolic Medicine, Osaka University Graduate School of Medicine, Japan
Munehide Matsuhisa
Diabetes Therapeutics and Research Center, The University of Tokushima, Japan
Iichiro Shimomura
Department of Metabolic Medicine, Osaka University Graduate School of Medicine, Japan

Keywords: progesterone, type 1 diabetes, insulin pump therapy, basal insulin

JOURNAL OPEN ACCESS

2013 Volume 52 Issue 2 Pages 259-262

DOI https://doi.org/10.2169/internalmedicine.52.8675

Details

Abstract

We herein report the case of a 37-year-old type 1 diabetic pregnant woman treated with an insulin pump. Although the patient's glycemic control deteriorated following progesterone treatment for the prevention of preterm delivery and miscarriage, it was improved by adjusting the basal insulin rate on the days of progesterone treatment. Excess progesterone is known to impair both insulin sensitivity and secretion. The present case is the first report to evaluate deterioration of glycemic control induced by progesterone treatment and to determine the dose of insulin required in a type 1 diabetic pregnant woman whose insulin secretion was completely depleted.

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