Internal Medicine
Online ISSN : 1349-7235
Print ISSN : 0918-2918
ISSN-L : 0918-2918
CASE REPORTS
Systemic Vasculitis Associated with Anti-Neutrophil Cytoplasmic Antibodies against Bactericidal/Permeability Increasing Protein
Atsuro FukuharaYoshinori TaninoSuguru SatoTaeko IshiiTakefumi NikaidoKenya KanazawaJunpei SaitoTakashi IshidaMakoto KannoTsuyoshi WatanabeMitsuru Munakata
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JOURNAL OPEN ACCESS

2013 Volume 52 Issue 10 Pages 1095-1099

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Abstract

Myeloperoxidase- and proteinase 3-anti-neutrophil cytoplasmic antibodies (ANCAs) are often negative in cases in which systemic vasculitis is highly suspected. We herein present a case of bactericidal/permeability increasing protein (BPI)-ANCA-positive systemic vasculitis. This case highlights the possible role of BPI-ANCA in the pathogenesis of systemic vasculitis as well as the possible use of BPI as a diagnostic tool. The accumulation of further case-based reports is expected to shed some light on the pathogesis of systemic vasculitis.

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© 2013 by The Japanese Society of Internal Medicine
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