Internal Medicine
Online ISSN : 1349-7235
Print ISSN : 0918-2918
ISSN-L : 0918-2918
CASE REPORTS
Two Rare Cases of Familial (Mother and Daughter) Adrenocorticotropic Hormone-independent Cushing's Syndrome due to Adrenal Adenoma, as well as the Asynchronous Development of Another Contralateral Adrenal Adenoma in the Mother
Atsushi OgoYuka SakakiNao HasuzawaRyoko SaitouYuka MatobaTakeshi UsuiMitsuhide Naruse
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JOURNAL OPEN ACCESS

2014 Volume 53 Issue 9 Pages 987-995

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Abstract

We herein report two cases involving a mother and daughter who presented with clinical features of Cushing's syndrome (CS) at 50 and 29 years of age, respectively, and were both found to have adrenocorticotropic hormone-independent adrenal adenoma. Furthermore, a new adenoma was detected in the contralateral adrenal gland in the mother 10 years after surgical treatment, when she presented with subclinical CS. The pathogenesis of this disorder, including the presence of unknown genetic abnormalities causing hereditary CS, is currently poorly understood. In this report, we describe our experience with and consider the pathophysiological implications of two rare and very interesting cases of familial CS.

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© 2014 by The Japanese Society of Internal Medicine
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