Journal of Oleo Science
Online ISSN : 1347-3352
Print ISSN : 1345-8957
ISSN-L : 1345-8957
Biochemistry and Biotechnology
Bovine lactoferrin reduces visceral fat and liver triglycerides in ICR mice
Satoru MorishitaTomoji OnoChikako FujisakiYasuharu IshiharaMichiaki MurakoshiHisanori KatoMasashi HosokawaKazuo MiyashitaKeikichi SugiyamaHoyoku Nishino
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2013 Volume 62 Issue 2 Pages 97-103

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Abstract

Lactoferrin (LF) is a multi-functional glycoprotein found in milk. In a previous clinical trial, we showed that enteric-coated bovine LF (bLF) tablets could reduce visceral fat accumulation. We also showed that bLF had anti-adipogenic activity in vitro. However, the mechanisms responsible for these phenomena remain unclear. In this study, we established an animal model of visceral fat reduction via oral bLF administration. We used gastric intubation to ensure that LF was absorbed in the small intestine. bLF administration for 4 weeks significantly reduced mesenteric fat tissue (P < 0.05) and hepatic triglyceride levels (P < 0.01). Furthermore, these two outcomes were positively correlated (R = 0.581, P < 0.05). Overall, these findings suggest that bLF affects mesenteric adipocytes and fatty acid metabolism in the liver.

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© 2013 by Japan Oil Chemists' Society
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