Astasia and Pyrexia Related to Borrelia garinii Infection in Two Dogs in Hokkaido, Japan

Hisashi INOKUMA; Shigeki MAETANI; Jyunji FUJITSUKA; Ai TAKANO; Kozue SATO; Takashi FUKUI; Toshiyuki MASUZAWA; Hiroki KAWABATA

doi:10.1292/jvms.13-0027

Internal Medicine

Astasia and Pyrexia Related to Borrelia garinii Infection in Two Dogs in Hokkaido, Japan

Hisashi INOKUMA, Shigeki MAETANI, Jyunji FUJITSUKA, Ai TAKANO, Kozue SATO, Takashi FUKUI, Toshiyuki MASUZAWA, Hiroki KAWABATA

Author information

Hisashi INOKUMA
Department of Clinical Veterinary Medicine, Obihiro University of Agriculture and Veterinary Medicine, Inada, Obihiro, Hokkaido, 080–8555, Japan
Shigeki MAETANI
Maetani Animal Hospital, Taihei, Kita-Ku, Sapporo, Hokkaido 002–8003, Japan
Jyunji FUJITSUKA
Maetani Animal Hospital, Taihei, Kita-Ku, Sapporo, Hokkaido 002–8003, Japan
Ai TAKANO
Department of Veterinary Medicine, Yamaguchi University, Yoshida, Yamaguchi 753–0815, Japan
Kozue SATO
Department of Bacteriology-I, National Institute of Infectious Diseases, Toyama, Shinjuku, Tokyo 162–8640, Japan
Takashi FUKUI
Faculty of Pharmacy, Chiba Institute of Science, Choshi, Chiba 288–0025, Japan
Toshiyuki MASUZAWA
Faculty of Pharmacy, Chiba Institute of Science, Choshi, Chiba 288–0025, Japan
Hiroki KAWABATA
Department of Bacteriology-I, National Institute of Infectious Diseases, Toyama, Shinjuku, Tokyo 162–8640, Japan

Keywords: Borrelia garinii, canine, Japan, Lyme disease

JOURNAL FREE ACCESS

2013 Volume 75 Issue 7 Pages 975-978

DOI https://doi.org/10.1292/jvms.13-0027

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Abstract

Two dogs that exhibited sudden astasia, anorexia and fever higher than 40°C were suspected of having Lyme disease in July 2011. Clinical symptoms gradually improved with antibiotic treatment in both cases. Polymerase chain reaction and sequence analysis revealed Borrelia garinii DNA fragments in the peripheral blood in the acute disease phase. Serological tests, including enzyme linked immunosorbent assay and Western blot analysis, showed an increased IgG antibody titer against Borrelia pathogens in one of the dogs. These findings suggested that diagnosis of the two dogs was Lyme disease related to B. garinii infection.

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