Acta Medica Nagasakiensia
Print ISSN : 0001-6055
Signal Transduction and Mood Disorders
Hiroki OZAWA
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2005 Volume 50 Issue 1 Pages 1-5

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Abstract

Several theories regarding pathophysiology of mood disorders (depression or bipolar disorders) and the mechanisms of therapeutic agents (antidepressnts or mood stabilizer) have been proposed. Inhibition of monoamine reuptake into nerve endings by antidepressants is one of the cornerstones of the monoamine hypothesis on depression. Many studies have focused on alterations in levels of monoamines and their receptors. More recent studies have been extended to examination of the post-receptor intracellular targets. These include several classes of the guanosine triphosphate-binding proteins that couple receptors and effectors, adenylate cyclase and the inositol phosphate second messenger system. This review summarizes studies on signal transduction and neural plasticity in terms of mood disorders.

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© 2005 by Nagasaki University School of Medicine
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