Wound healing process is highly organized, regulated and orchestrated by cellular and molecular basis. As for biology, wound healing is very much attractive to multi-subspecialty fields of both basic and clinical medicine. Clinical problems of wound healing also extend a single sub-specialty of medicine, not only surgeries but internal-, social-, psychological- medicine. Thorough comprehension of clinical and futuristic approaches for this complex entity is recommended. Based upon a number of clinical experiences of wound-related problems, starting with burns, trauma to chronic intractable wounds and subsequent unfavorable scar formation, the clinically relevant evaluations for wound healing is presented including life-saving modalities, minimizing the scar formation or scarless wound healing, prognosis predictors. Also, clinical related-basic research brought about regenerative medical solutions using artificial dermis, cytokine and adult stem cells. Acute and chronic difficult wound healing should be holistically approached and "emergency primary wound healing center" will be most appreciated for any form of biological, chemical, nuclear and radiation-related issues. In this context, Nagasaki University may be able to play a pivotal role in global view point.