Spontaneous Seroconversion of Hepatitis B Surface Antigen in a Young Woman with Chronic Carrier

Katsuhisa OMAGARI; Jun-ichi MASUDA; Hideki KINOSHITA; Shiho AKAZAWA; Yoshiko KADOKAWA; Hiroaki HAZAMA; Kazuo OHBA; Ken OHNITA; Kenji HAYASHIDA; Yohei MIZUTA; Shigeru KOHNO

doi:10.11343/amn.51.69

Katsuhisa OMAGARI, Jun-ichi MASUDA, Hideki KINOSHITA, Shiho AKAZAWA, Yoshiko KADOKAWA, Hiroaki HAZAMA, Kazuo OHBA, Ken OHNITA, Kenji HAYASHIDA, Yohei MIZUTA, Shigeru KOHNO

Author information

Katsuhisa OMAGARI
Second Department of Internal Medicine, Nagasaki University School of Medicine
Jun-ichi MASUDA
Second Department of Internal Medicine, Nagasaki University School of Medicine
Department of Internal Medicine, Goto Chuo Hospital
Hideki KINOSHITA
Department of Internal Medicine, Goto Chuo Hospital
Shiho AKAZAWA
Second Department of Internal Medicine, Nagasaki University School of Medicine
Yoshiko KADOKAWA
Second Department of Internal Medicine, Nagasaki University School of Medicine
Hiroaki HAZAMA
Second Department of Internal Medicine, Nagasaki University School of Medicine
Kazuo OHBA
Second Department of Internal Medicine, Nagasaki University School of Medicine
Ken OHNITA
Second Department of Internal Medicine, Nagasaki University School of Medicine
Kenji HAYASHIDA
Second Department of Internal Medicine, Nagasaki University School of Medicine
Yohei MIZUTA
Second Department of Internal Medicine, Nagasaki University School of Medicine
Shigeru KOHNO
Second Department of Internal Medicine, Nagasaki University School of Medicine

Keywords: Hepatitis B virus, Hepatitis B surface antigen, Seroconversion

JOURNAL FREE ACCESS

2006 Volume 51 Issue 2 Pages 69-72

DOI https://doi.org/10.11343/amn.51.69

Details

Abstract

The incidence of spontaneous seroconversion of hepatitis B surface antigen (HBsAg) in the natural history of patients with chronic hepatitis B virus (HBV) infection is considered to be low in patients aged under 40 years. The clinical course and outcome of chronic HBV infection are complex and heterogeneous, and may be influenced by many factors such as HBV genotype, viral mutations, gender, age, host immune status, other viral co-infections, and alcohol consumption. We encountered a Japanese woman in whom HBsAg seroconversion had occurred when she was 32 years old, 3 years after she had given birth without any anti-viral therapy. In this case, alcohol intake, pregnancy and delivery may have affected the host-virus interaction.

Corresponding author

Register with J-STAGE for free!