Effects of Pro-Hyp, a Collagen Hydrolysate-Derived Peptide, on Hyaluronic Acid Synthesis Using in Vitro Cultured Synovium Cells and Oral Ingestion of Collagen Hydrolysates in a Guinea Pig Model of Osteoarthritis

Hiroki OHARA; Hiroyuki IIDA; Kyoko ITO; Yasuo TAKEUCHI; Yoshihiro NOMURA

doi:10.1271/bbb.100193

Food & Nutrition Science Notes

Effects of Pro-Hyp, a Collagen Hydrolysate-Derived Peptide, on Hyaluronic Acid Synthesis Using in Vitro Cultured Synovium Cells and Oral Ingestion of Collagen Hydrolysates in a Guinea Pig Model of Osteoarthritis

Hiroki OHARA, Hiroyuki IIDA, Kyoko ITO, Yasuo TAKEUCHI, Yoshihiro NOMURA

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Keywords: proline-hydroxyproline (Pro-Hyp), hyaluronic acid, collagen hydrolysates, osteoarthritis, proteoglycan

JOURNAL FREE ACCESS

2010 Volume 74 Issue 10 Pages 2096-2099

DOI https://doi.org/10.1271/bbb.100193

View "Advance Publication" version (October 7, 2010).

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Abstract

Proline-hydroxyproline (Pro-Hyp) stimulated hyaluronic acid production in cultured synovium cells. It was detected in guinea pig blood after oral ingestion of collagen hydrolysates. Oral administration of collagen hydrolysates increased the amount of proteoglycans in the epiphyses. It also reduced the morphological changes associated with osteoarthritic cartilage destruction of the knee joint. The results suggest that collagen hydrolysates have therapeutic potential for treatment of osteoarthritis.

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