Bioscience, Biotechnology, and Biochemistry
Online ISSN : 1347-6947
Print ISSN : 0916-8451
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Multiple Functions of the S-Phase Checkpoint Mediator
Katsunori TANAKA
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JOURNAL FREE ACCESS

2010 Volume 74 Issue 12 Pages 2367-2373

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Abstract

There is mounting evidence that replication defects are the major source of spontaneous genomic instability in cells, and that S-phase checkpoints are the principal defense against such instability. The S-phase checkpoint mediator protein Mrc1/Claspin mediates the checkpoint response to replication stress by facilitating phosphorylation of effector kinase by a sensor kinase. In this review, the multiple functions and the regulation of the S-phase checkpoint mediator are discussed.

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© 2010 by Japan Society for Bioscience, Biotechnology, and Agrochemistry
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