Mechanism of the Lifespan Extension of Caenorhabditis elegans by Electrolyzed Reduced Water—Participation of Pt Nanoparticles

Hanxu YAN; Tomoya KINJO; Huaize TIAN; Takeki HAMASAKI; Kiichiro TERUYA; Shigeru KABAYAMA; Sanetaka SHIRAHATA

doi:10.1271/bbb.110072

Biochemistry & Molecular Biology Regular Papers

Mechanism of the Lifespan Extension of Caenorhabditis elegans by Electrolyzed Reduced Water—Participation of Pt Nanoparticles

Hanxu YAN, Tomoya KINJO, Huaize TIAN, Takeki HAMASAKI, Kiichiro TERUYA, Shigeru KABAYAMA, Sanetaka SHIRAHATA

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Keywords: electrolyzed reduced water, Caenorhabditis elegans, lifespan, reactive oxygen species, Pt nanoparticles

JOURNAL FREE ACCESS

2011 Volume 75 Issue 7 Pages 1295-1299

DOI https://doi.org/10.1271/bbb.110072

View "Advance Publication" version (July 7, 2011).

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Abstract

Electrolyzed reduced water (ERW) contains a large amount of molecular hydrogen and a small amount of Pt nanoparticles (Pt NPs). We have found that ERW significantly extended the lifespan of Caenorhabditis elegans in a novel culture medium designated Water Medium. In this study, we found that synthetic Pt NPs at ppb levels significantly extended the nematode lifespan and scavenged reactive oxygen species (ROS) in the nematode induced by paraquat treatment. In contrast, a high concentration of dissolved molecular hydrogen had no significant effect on the lifespan of the nematode. These findings suggest that the Pt NPs in ERW, rather than the molecular hydrogen, extend the longevity of the nematode, at least partly by scavenging ROS.

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