Effect of Vaccinium ashei reade Leaf Extracts on Lipid Metabolism in Obese OLETF Rats

Nao INOUE; Koji NAGAO; Saori NOMURA; Bungo SHIROUCHI; Masashi INAFUKU; Hideaki HIRABARU; Noriaki NAKAHARA; Shoko NISHIZONO; Takashi TANAKA; Teruyoshi YANAGITA

doi:10.1271/bbb.110451

Food & Nutrition Science Regular Papers

Effect of Vaccinium ashei reade Leaf Extracts on Lipid Metabolism in Obese OLETF Rats

Nao INOUE, Koji NAGAO, Saori NOMURA, Bungo SHIROUCHI, Masashi INAFUKU, Hideaki HIRABARU, Noriaki NAKAHARA, Shoko NISHIZONO, Takashi TANAKA, Teruyoshi YANAGITA

Author information

Nao INOUE
Department of Applied Biochemistry and Food Science, Saga University
Graduate School of Agricultural Science, Tohoku University
Koji NAGAO
Department of Applied Biochemistry and Food Science, Saga University
Saori NOMURA
Department of Applied Biochemistry and Food Science, Saga University
Bungo SHIROUCHI
Department of Applied Biochemistry and Food Science, Saga University
Masashi INAFUKU
Department of Applied Biochemistry and Food Science, Saga University
Hideaki HIRABARU
Research Institute, Unkai Shuzo Co., Ltd.
Noriaki NAKAHARA
Research Institute, Unkai Shuzo Co., Ltd.
Shoko NISHIZONO
Cooperative Research Center, University of Miyazaki
Takashi TANAKA
Graduate School of Biomedical Sciences, Nagasaki University
Teruyoshi YANAGITA
Department of Applied Biochemistry and Food Science, Saga University

Keywords: blueberry leaf, flavonol glycoside, proanthocyanidin, lipid metabolism, Otsuka Long-Evans Tokushima Fatty rat

JOURNAL FREE ACCESS

2011 Volume 75 Issue 12 Pages 2304-2308

DOI https://doi.org/10.1271/bbb.110451

View "Advance Publication" version (December 7, 2011).

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Abstract

The effects of a hot water extract and fractional extracts from rabbiteye blueberry (Vaccinium ashei reade) leaves (BBL) on lipid metabolism were studied in obese Otsuka Long-Evans Tokushima Fatty (OLETF) rats. Feeding the hot water extract and fractional extracts from BBL alleviated hepatic triglyceride accumulation in the rats. Additionally, feeding with the flavonol glycoside (FG) and proanthocyanidin (PA) fractions lowered serum cholesterol levels in the obese rats. The results from measurements of the hepatic enzyme activity indicate that the hypolipidemic effects of the hot water extract and the PA fraction might be attributable to enhanced lipolysis in the liver. The reduced serum levels of C-reactive protein, an inflammatory cytokine, by the chlorogenic acid + rutin fraction and FG fraction might be associated with alleviating the metabolic abnormalities in obese rats. These results indicate that the BBL extracts, and especially FG and PA, exerted hypolipidemic effects on obese OLETF rats and suggest that an infusion of BBL can be useful as a dietary hypolipidemic component.

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