Bioscience, Biotechnology, and Biochemistry
Online ISSN : 1347-6947
Print ISSN : 0916-8451
Food & Nutrition Science Notes
Lupeol Supplementation Improves Blood Pressure and Lipid Metabolism Parameters in Stroke-Prone Spontaneously Hypertensive Rats
ARDIANSYAHEri YAMAGUCHIHitoshi SHIRAKAWAKeishi HATAKazuyuki HIWATASHIKousaku OHINATATomoko GOTOMichio KOMAI
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2012 Volume 76 Issue 1 Pages 183-185

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Abstract

Supplementation with lupeol (0.67 g·kg−1) of the AIN-93M-based diet fed for 7 weeks to stroke-prone spontaneously hypertensive rats caused significantly decreased blood pressure as compared with a control group. Urinary 8-hydroxy-2′-deoxyguanosine was significantly lower in the lupeol group. Finally, lupeol suppressed the hepatic mRNA expression levels of the genes involved in triglyceride and cholesterol synthesis.

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© 2012 by Japan Society for Bioscience, Biotechnology, and Agrochemistry
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