Bioscience, Biotechnology, and Biochemistry
Online ISSN : 1347-6947
Print ISSN : 0916-8451
Organic Chemistry Regular Papers
Antioxidative and Anti-Inflammatory Activities of Polyhydroxyflavonoids of Scutellaria baicalensis GEORGI
Wen-Hsin HUANGAn-Rong LEEChing-Huey YANG
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JOURNAL FREE ACCESS

2006 Volume 70 Issue 10 Pages 2371-2380

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Abstract

The active ingredients of ‘golden root’ of Scutellaria baicalensis GEORGI (Huang-Qin), a valuable traditional Chinese medicine, are polyhydroxyflavonoids, namely baicalein, oroxylin A and wogonin. With the objective of overcoming their poor solubility and to investigate their structure and activity relationships, baicaleinyl 7-O-sulfate was prepared, and extensive comparative antioxidative and anti-inflammatory tests were conducted. All the polyhydroxyflavonoids exhibited significant antioxidative and free-radical scavenging activities. In respect of their nitric oxide (NO) inhibition, wogonin was superior to all the other flavonoids, while oroxylin A was most potent in the inhibition of lipid peroxidation. Wogonin proved to be the most potent (82.9% inhibition, p<0.05) in its anti-inflammatory activity against carrageenan-induced rat hind paw edema. There was a correlation between the in-vivo anti-inflammatory activity and the in-vitro antioxidative activities.

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© 2006 by Japan Society for Bioscience, Biotechnology, and Agrochemistry
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