Oral Administration of an Immunostimulatory DNA Sequence from Bifidobacterium longum Improves Th1/Th2 Balance in a Murine Model

Noritoshi TAKAHASHI; Haruki KITAZAWA; Noriyuki IWABUCHI; Jin-Zhong XIAO; Kazuhiro MIYAJI; Keiji IWATSUKI; Tadao SAITO

doi:10.1271/bbb.60260

Food & Nutrition Science Communication

Oral Administration of an Immunostimulatory DNA Sequence from Bifidobacterium longum Improves Th1/Th2 Balance in a Murine Model

Noritoshi TAKAHASHI, Haruki KITAZAWA, Noriyuki IWABUCHI, Jin-Zhong XIAO, Kazuhiro MIYAJI, Keiji IWATSUKI, Tadao SAITO

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Keywords: probiotics, immunostimulatory DNA, immunoglobulin (Ig) E, allergy, Bifidobacterium longum BB536

JOURNAL FREE ACCESS

2006 Volume 70 Issue 8 Pages 2013-2017

DOI https://doi.org/10.1271/bbb.60260

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Abstract

We have reported the antiallergic activities of the immunostimulatory oligodeoxynucleotide (ODN) BL07S, identified from genomic DNA of Bifidobacterium longum BB536 from in vitro and in vivo studies. The present study evaluated the efficiency of ODN BL07S in preventing allergic responses by oral administration. Oral administration of BL07S suppressed serum ovalbumin (OVA)-specific immunoglobulin (Ig) E levels and improved the OVA-specific IgG2a/IgG1 ratio. ODN BL07S increased Th1 cytokine and decreased Th2 cytokine production in splenocytes. These results suggest that immunostimulatory ODNs are potentially associated with the antiallergic effects of probiotics.

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