Bioscience, Biotechnology, and Biochemistry
Online ISSN : 1347-6947
Print ISSN : 0916-8451
Microbiology & Fermentation Industry Notes
Multidrug Resistance Phenotype Conferred by Overexpressing bfr2+/pad1+/sks1+ or pap1+ Genes and Mediated by bfr1+ Gene Product, a Structural and Functional Homologue of P-Glycoprotein in Schizosaccharomyces pombe
Manabu ARIOKA, Mutsuo KOUHASHI, Koji YODA, Akira TAKATSUKI, Makari YAMASAKI, Katsuhiko KITAMOTO
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Keywords: ATP-binding cassette (ABC) superfamily, brefeldin A, multidrug resistance (MDR), bfr1+ gene, pad1+ gene
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1998 Volume 62 Issue 2 Pages 390-392

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Abstract

  We investigated the mechanism of multidrug resistance conferred by overexpression of bfr2+/pad1+/sks1+ or pap1+ genes of Schizosaccharomyces pombe. Overexpression of bfr2+ did not confer multidrug resistance on a pap1-disrupted strain. In a mutant with bfr1+ (a putative membrane transporter which belongs to the ATP-binding cassette superfamily) disrupted, overexpression of either bfr2+ or pap1+ did not confer multidrug resistance. These findings suggest that bfr1+ acts as the most downstream effector of the multidrug resistance conferred by bfr2+ and pap1+ genes.

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© 1998 by Japan Society for Bioscience, Biotechnology, and Agrochemistry
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