Theanine-induced Reduction of Brain Serotonin Concentration in Rats

Hidehiko YOKOGOSHI; Mikiko MOCHIZUKI; Kotomi SAITOH

doi:10.1271/bbb.62.816

Bioscience, Biotechnology, and Biochemistry

Online ISSN : 1347-6947
Print ISSN : 0916-8451

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Theanine-induced Reduction of Brain Serotonin Concentration in Rats

Hidehiko YOKOGOSHI, Mikiko MOCHIZUKI, Kotomi SAITOH

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Keywords: theanine, tryptophan, brain serotonin, neurotransmitter, rat

JOURNAL FREE ACCESS

1998 Volume 62 Issue 4 Pages 816-817

DOI https://doi.org/10.1271/bbb.62.816

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Abstract

Following the administration of theanine, the brain tryptophan content significantly increased or tended to increase, but the contents of serotonin and 5-hydroxyindole acetic acid (5HIAA) decreased. The use of inhibitors of serotonin metabolism enable us to speculate that theanine reduced serotonin synthesis and also increased serotonin degradation in the brain.

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