Steroid 5α-Reductase Inhibitory Activity and Hair Regrowth Effects of an Extract from Boehmeria nipononivea

Kuniyoshi SHIMIZU; Ryuichiro KONDO; Kokki SAKAI; Yoshihiro SHOYAMA; Hiroaki SATO; Tetsuya UENO

doi:10.1271/bbb.64.875

Organic Chemistry Notes

Steroid 5α-Reductase Inhibitory Activity and Hair Regrowth Effects of an Extract from Boehmeria nipononivea

Kuniyoshi SHIMIZU, Ryuichiro KONDO, Kokki SAKAI, Yoshihiro SHOYAMA, Hiroaki SATO, Tetsuya UENO

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Keywords: Boehmeria nipononivea, hair regrowth, testosterone 5α-reductase inhibitor, fatty acid, Urticaceae

JOURNAL FREE ACCESS

2000 Volume 64 Issue 4 Pages 875-877

DOI https://doi.org/10.1271/bbb.64.875

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Abstract

The acetone extract of Boehmeria nipononivea showed both potent 5α-reductase inhibitory activity and hair regrowth promotion effects on mice. 5α-Reductase inhibitory activity-guided fractionation led to six active fatty acids: α-linolenic, linoleic, palmitic, elaidic, oleic and stearic acids. The extract of B. nipononivea, and α-linolenic, elaidic and stearic acids exhibited a hair regrowth effect.

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