Food & Nutrition Science
Acetyl-CoA Carboxylase Inhibitors from Avocado (Persea americana Mill) Fruits
2001 Volume 65 Issue 7 Pages 1656-1658
Details
2001 Volume 65 Issue 7 Pages 1656-1658
A methanol extract of avocado fruits showed potent inhibitory activity against acetyl-CoA carboxylase, a key enzyme in fatty acid biosynthesis. The active principles were isolated and identified as (5E,12Z,15Z)-2-hydroxy-4-oxoheneicosa-5,12,15-trienyl (1), (2R,12Z,15Z)-2-hydroxy-4-oxoheneicosa-12,15-dienyl (2), (2R*,4R*)-2,4-dihydroxyheptadec-16-enyl (3) and (2R*,4R*)-2,4-dihydroxyheptadec-16-ynyl (4) acetates by instrumental analyses. The IC50 of the compounds were 4.0×10-6, 4.9×10-6, 9.4×10-6, and 5.1×10-6M, respectively.
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