Translational Regulation of the mRNA Encoding the Eukaryotic Translation Initiation Factor 4E in Xenopus

Motoaki WAKIYAMA; Motoki SAIGOH; Kayoko IKEDA; Aki SUZUKI; Kin-ichiro MIURA

doi:10.1271/bbb.65.229

Bioscience, Biotechnology, and Biochemistry

Online ISSN : 1347-6947
Print ISSN : 0916-8451

Biochemistry & Molecular Biology

Translational Regulation of the mRNA Encoding the Eukaryotic Translation Initiation Factor 4E in Xenopus

Motoaki WAKIYAMA, Motoki SAIGOH, Kayoko IKEDA, Aki SUZUKI, Kin-ichiro MIURA

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Keywords: translational regulation, translation initiation factor 4E, Xenopus, oocytes

JOURNAL FREE ACCESS

2001 Volume 65 Issue 1 Pages 229-231

DOI https://doi.org/10.1271/bbb.65.229

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Abstract

We have cloned the cDNA for Xenopus eukaryotic translation initiation factor 4E (eIF4E). Here we show that translation of a luciferase mRNA that contains the 5' untranslated region derived from Xenopus eIF4E is active in fertilized eggs, but is repressed in oocytes. The results suggest that the expression of Xenopus eIF4E is regulated at the translation level.

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