Antibacterial Agents that Inhibit Histidine Protein Kinase YycG of Bacillus subtilis

Kaneyoshi YAMAMOTO; Takashi KITAYAMA; Shu MINAGAWA; Takafumi WATANABE; Seiji SAWADA; Tadashi OKAMOTO; Ryutaro UTSUMI

doi:10.1271/bbb.65.2306

Biochemistry & Molecular Biology

Antibacterial Agents that Inhibit Histidine Protein Kinase YycG of Bacillus subtilis

Kaneyoshi YAMAMOTO, Takashi KITAYAMA, Shu MINAGAWA, Takafumi WATANABE, Seiji SAWADA, Tadashi OKAMOTO, Ryutaro UTSUMI

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Keywords: two-component system, signal transduction, histidine kinase inhibitors, antimicrobial agents

JOURNAL FREE ACCESS

2001 Volume 65 Issue 10 Pages 2306-2310

DOI https://doi.org/10.1271/bbb.65.2306

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Abstract

We demonstrated in vitro that YycG-YycF of Bacillus subtillis constitutes a two-component system and shows a specificity of the sensor protein for the cognate phosphorylation partner. Based on inhibition of such an autophosphorylation of YycG, we searched imidazole and zerumbone derivatives to identify the antibacterial agents such as NH125, NH126, NH127, and NH0891.

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