Bioscience, Biotechnology, and Biochemistry
Online ISSN : 1347-6947
Print ISSN : 0916-8451
Microbiology & Fermentation Technology Regular Papers
Isoflavone Aglycon Produced by Culture of Soybean Extracts with Basidiomycetes and Its Anti-angiogenic Activity
Takehito MIURALan YUANBuxiang SUNHajime FUJIIMayumi YOSHIDAKoji WAKAMEKen-ichi KOSUNA
Author information
JOURNAL FREE ACCESS

2002 Volume 66 Issue 12 Pages 2626-2631

Details
Abstract

  Soybean extracts (SBE) containing isoflavone glycosides were cultured with Ganoderma lucidum mycelia producing β-glucosidase. The anti-angiogenic effects of the cultivated product, containing rich in genistein, named GCP (genistein combined polysaccharide), were assessed with chick chorioallantoic membranes (CAM) and a mouse dorsal air-sac model. β-Glucosidase produced by the mycelia converted the isoflavone glycosides into aglycons. A test of volunteers showed that serum concentrations of genistein in the subjects treated with GCP (n=4) at 3 h after administration were significantly higher than those in the subjects treated with SBE (n=4).
  GCP inhibited angiogenesis in CAM, and the activity of GCP was greater than that of SBE. GCP inhibited the formation of new vessels induced by colon carcinoma cells in vivo.

Content from these authors

This article cannot obtain the latest cited-by information.

© 2002 by Japan Society for Bioscience, Biotechnology, and Agrochemistry
Previous article Next article
feedback
Top