Bioscience, Biotechnology, and Biochemistry
Online ISSN : 1347-6947
Print ISSN : 0916-8451
Food & Nutrition Science Notes
Procyanidin B1 Is Detected in Human Serum after Intake of Proanthocyanidin-rich Grape Seed Extract
Atsushi SANOJun YAMAKOSHIShoichi TOKUTAKEKoichiro TOBEYoshiro KUBOTAMamoru KIKUCHI
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2003 Volume 67 Issue 5 Pages 1140-1143

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Abstract

  To confirm the absorption of proanthocyanidin (PA) into the human body, four healthy adults were administered 2.0 g of PA-rich grape seed extract (GSE). Blood were drawn before intake and 2 h after intake. Through the enzymatic treatment of sulfatase and β-glucuronidase, blood samples were analyzed by HPLC coupled with mass-spectrometry (LC/MS). Procyanidin B1 [epicatechin-(4β→8)-catechin] was detected in human serum 2 h after intake. Its concentration was 10.6±2.5 nmol/l.

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© 2003 by Japan Society for Bioscience, Biotechnology, and Agrochemistry
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