Effect of Methanol Extract of Zanthoxylum piperitum Leaves and of Its Compound, Protocatechuic Acid, on Hepatic Drug Metabolizing Enzymes and Lipid Peroxidation in Rats

Jong Moon HUR; Ju Gwon PARK; Ki Ho YANG; Jong Cheol PARK; Jeong Ro PARK; Soon Sil CHUN; Jae Sue CHOI; Jong Won CHOI

doi:10.1271/bbb.67.945

Food & Nutrition Science Regular Papers

Effect of Methanol Extract of Zanthoxylum piperitum Leaves and of Its Compound, Protocatechuic Acid, on Hepatic Drug Metabolizing Enzymes and Lipid Peroxidation in Rats

Jong Moon HUR, Ju Gwon PARK, Ki Ho YANG, Jong Cheol PARK, Jeong Ro PARK, Soon Sil CHUN, Jae Sue CHOI, Jong Won CHOI

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Keywords: bromobenzene, Zanthoxylum piperitum, protocatechuic acid, drug-metabolizing enzyme, lipid peroxidation

JOURNAL FREE ACCESS

2003 Volume 67 Issue 5 Pages 945-950

DOI https://doi.org/10.1271/bbb.67.945

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Abstract

The effect of methanol extract and protocatechuic acid from the leaves of Zanthoxylum piperitum on lipid peroxidation and drug metabolizing enzymes were investigated in the liver of bromobenzene-treated rats. The methanol extract and protocatechuic acid reduced the level of lipid peroxide induced by bromobenzene. The methanol extract and protocatechuic acid reduced the activity of aniline hydroxylase that had been increased by bromobenzene, while did not affect the activities of aminopyrine N-demethylase and glutathione S-transferase. The methanol extract and compound effectively restored the activity of epoxide hydrolase which had been decreased by bromobenzene. These results may suggest that the methanol extract of Z. piperitum and protocatechuic acid prevented lipid peroxidation by reducing the activity of aniline hydroxylase, an epoxide-producing enzyme, and by enhancing the activity of epoxide hydrolase, an epoxide-removing enzyme, in rats that had been intoxicated with bromobenzene.

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