Bioscience, Biotechnology, and Biochemistry
Online ISSN : 1347-6947
Print ISSN : 0916-8451
Food & Nutrition Science Notes
Effect of Ascorbate on Acrolein Modification of Very Low Density Lipoprotein and Uptake of Oxidized Apolipoprotein E by Hepatocytes
Hirofumi ARAIKoji UCHIDAKazuyuki NAKAMURA
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JOURNAL FREE ACCESS

2005 Volume 69 Issue 9 Pages 1760-1762

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Abstract

Acrolein modification of apolipoprotein (apo) E in human very low density lipoprotein (VLDL) was suppressed by ascorbate. Acrolein-modified apoE in VLDL was not taken up by human hepatoma cell whereas unmodified apoE in the presence of ascorbate was taken up. These results suggest that ascorbate can play an important role in maintaining proper lipoprotein metabolism by the antioxidant effect.

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© 2005 by Japan Society for Bioscience, Biotechnology, and Agrochemistry
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