Bioscience, Biotechnology, and Biochemistry
Online ISSN : 1347-6947
Print ISSN : 0916-8451
Microbiology & Fermentation Technology Communication
Characterization of the NikA Histidine Kinase Implicated in the Phosphorelay Signal Transduction of Aspergillus nidulans, with Special Reference to Fungicide Responses
Daisuke HAGIWARAYoshihiro MATSUBAYASHIJunichiro MARUIKentaro FURUKAWATakafumi YAMASHINOKyoko KANAMARUMasashi KATOKeietsu ABETetsuo KOBAYASHITakeshi MIZUNO
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2007 Volume 71 Issue 3 Pages 844-847

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Abstract

We recently compiled a complete list of phosphorelay signal transduction components in the model filamentous fungus Aspergillus nidulans. In this study, we characterized a histidine protein kinase (designated NikA) that is found in many fungi, with special reference to responses to potent fungicides (iprodione and fludioxonil). We provided evidence that not only NikA, but also two downstream response regulators (SskA and SrrA) are crucially implicated in the mode of action of these fungicides, and also that the further downstream HogA-MAPK cascade is exaggerated abnormally (or ectopically) in hyphae by the fungicides in a manner dependent on the NikA-SskA phosphorelay.

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© 2007 by Japan Society for Bioscience, Biotechnology, and Agrochemistry
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