Differences in Developing Intestinal Microbiota between Allergic and Non-Allergic Infants: A Pilot Study in Japan

Prapa SONGJINDA; Jiro NAKAYAMA; Atsushi TATEYAMA; Shigemitsu TANAKA; Mina TSUBOUCHI; Chikako KIYOHARA; Taro SHIRAKAWA; Kenji SONOMOTO

doi:10.1271/bbb.70154

Microbiology & Fermentation Technology Communication

Differences in Developing Intestinal Microbiota between Allergic and Non-Allergic Infants: A Pilot Study in Japan

Prapa SONGJINDA, Jiro NAKAYAMA, Atsushi TATEYAMA, Shigemitsu TANAKA, Mina TSUBOUCHI, Chikako KIYOHARA, Taro SHIRAKAWA, Kenji SONOMOTO

Author information

Prapa SONGJINDA
Department of Bioscience and Biotechnology, Faculty of Agriculture, Graduate School, Kyushu University
Jiro NAKAYAMA
Department of Bioscience and Biotechnology, Faculty of Agriculture, Graduate School, Kyushu University
Atsushi TATEYAMA
Department of Bioscience and Biotechnology, Faculty of Agriculture, Graduate School, Kyushu University
Shigemitsu TANAKA
Department of Bioscience and Biotechnology, Faculty of Agriculture, Graduate School, Kyushu University
Mina TSUBOUCHI
Department of Health Promotion and Human Behavior, Kyoto University, Graduate School of Public Health
Chikako KIYOHARA
Department of Preventive Medicine, Division of Social Medicine, Graduate School of Medical Sciences, Kyushu University
Taro SHIRAKAWA
Department of Health Promotion and Human Behavior, Kyoto University, Graduate School of Public Health
Kenji SONOMOTO
Department of Bioscience and Biotechnology, Faculty of Agriculture, Graduate School, Kyushu University
Department of Functional Metabolic Design, Bio-Architecture Center, Kyushu University

Keywords: infant, allergy, gastrointestinal (GI)-tract microbiota, feces, bacteroides

JOURNAL FREE ACCESS

2007 Volume 71 Issue 9 Pages 2338-2342

DOI https://doi.org/10.1271/bbb.70154

View "Advance Publication" version (September 7, 2007).

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Abstract

The bacterial compositions of feces were monitored in the first 2 months for 15 infants born in Japan, including eight subjects who developed allergy by the age of 2 years. Primer sets targeting six predominant bacterial groups in the infant intestine, Bacteroidaceae, Enterobacteriaceae, bifidobacteria, enterococci, lactobacilli, and the Clostridium perfringens group, were used for real-time PCR to quantitate each population in the feces. The population of Bacteroidaceae was significantly higher in the allergic group at the ages of 1 month (P=0.03) and 2 months (P=0.05) than in the non-allergic group, while no statistically significant difference was observed for the other bacterial populations.

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